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Multiple Sclerosis In Vivo Models

In addition to our world-leading in vitro expertise, we understand the importance of in vivo models in accelerating your best route to clinic.

Leveraging and combining our neuroscience and immunology expertise, Aquila offer pre-clinical animal models for MS, which focus on the autoimmune and inflammatory component of the disease as well as the myelin damage and repair.

Cuprizone and LPC Models

The cuprizone and lysophosphatidylcholine (LPC) rodent models induce demyelination followed by a recovery period of remyelination. The cuprizone model results in global demyelination whereas the LPC induced model creates a focal lesion.

We can support on the best in vivo model for your question as well as customise the readouts: tailored H&E, specialist multiplex histology and FACS readouts are available. We work closely with you to identify how your novel therapy affects the MS injury or repair process, to build a stronger data package and speed up your route to clinic.

Contact us to find out how we can support your Multiple Sclerosis research.

EAE model

Experimental autoimmune encephalomyelitis (EAE) is a T cell-driven disease of the central nervous system in mouse and is considered the gold standard model for brain inflammation and demyelination studies.

Cuprizone and LPC Models

The cuprizone and lysophosphatidylcholine (LPC) rodent models induce demyelination followed by a recovery period of remyelination. The cuprizone model results in global demyelination whereas the LPC induced model creates a focal lesion.

We can support on the best in vivo model for your question as well as customise the readouts: tailored H&E, specialist multiplex histology and FACS readouts are available. We work closely with you to identify how your novel therapy affects the MS injury or repair process, to build a stronger data package and speed up your route to clinic.

Contact us to find out how we can support your Multiple Sclerosis research.

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