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Organotypic Brain Slice Assays

Our expert scientists. Your drug discovery pipeline.

Understanding the functional response to your CNS drug candidate in a more complex in vitro environment can more efficiently progress your drug discovery program to clinic.

At Aquila, we offer brain slice assays as a low-throughput validation model of your test compound in a complex, multicellular approach. Slice cultures contain and maintain all the relevant neuronal and glial cells, structure and organisation of the brain in thick sections of cultured ex vivo tissue providing a powerful translational link between in vitro and in vivo CNS studies in important therapeutic areas such as MS, Parkinson’s and Alzheimer’s disease.

We tailor the assay readouts to suit you. These can include immunohistochemical-based analysis or gene expression studies using qPCR or NGS techniques.

Contact us today to discuss how we can support your CNS research program.